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Mimba pambuyo pakuika maselo osunthika nthawi zambiri imakhala nkhani yovuta ndipo imasamalidwa kwambiri. Kafukufuku wasonyeza kuti kupambana pakukhala ndi pakati pambuyo pofalitsa ma cell am'magazi kumadalira pazinthu zambiri monga kuchuluka kwa radiation ndi chemotherapy, komanso zaka za amayi pa nthawi yoika.
Munkhaniyi, tikambirana za zotsatira za mimba pambuyo pobzala mbeu. Onani.
Kodi Kuika Maselo a Tsinde Ndi Chiyani?
Kuika ma cell a stem ndi njira yomwe maselo amtundu wathanzi amaperekedwa kwa odwala omwe ali ndi mafupa osagwira ntchito kapena omwe atha. Njirayi imathandizira kukonza magwiridwe antchito a mafupa ndipo imalola kupha ma cell a khansa kapena kupangika kwa maselo athanzi m'malo mwa omwe ali osagwira ntchito. [1]
Kutchula, maselusi amtunduwu ndi ma cell apadera m'thupi omwe amatha kusintha kukhala mtundu wina uliwonse wamthupi ndipo amatha kudzipanganso okha, pomwe mafuta am'mafupa ndimatumba ofewa m'mafupa omwe amapanga ndikusunga tsinde maselo.
Kuika ma cell a stem kumatha kuwonjezera kuchuluka kwa odwala omwe ali ndi zotupa za haematological kapena zokhudzana ndi magazi, matenda osowa chitetezo chamthupi kapena matenda ena.
N 'chifukwa Chiyani Mimba Pambuyo Pakusanjika Kwa Maselo Akumapazi Kuli Kovuta?
Amayi omwe adayambapo kapena kuyamba ndi kuziika kwa khungu nthawi zambiri amakhala ndi nkhawa zakubala kwawo komanso mwayi wokhala ndi pakati pambuyo pochita izi.
Ngakhale kuziika kumathandizira kukulitsa kuchuluka kwa anthu omwe ali ndi mitundu ina ya khansa monga khansa ya m'magazi kapena lymphoma, odwala nthawi zambiri amakumana ndi zovuta za kubereka chifukwa cha kuwonongeka kwa ziwalo zoberekera monga mazira oyambitsidwa ndi mapuloteni oyambitsirana.
Ndondomekozi zimaphatikizapo kugwiritsa ntchito alkylating agents, radiation, kapena zonse ziwiri zomwe zimakhala ndi zotsatira zoyipa mthupi. [ziwiri]
Komanso, ngakhale mayi atakwanitsa kukhala ndi pakati mwachilengedwe kapena mwa njira za vitro feteleza, pamakhala chiopsezo chowonjezeka chobadwa ndi mwana, msinkhu, kutaya mimba kapena zovuta zina za mimba.
Kodi Zowonongeka Zingasinthidwe?
Kuwonongeka komwe kumachitika chifukwa chakuyika kwa ma cell kwa amayi kumatha kuwapangitsa kukhala osabereka mpaka kalekale, pomwe ena amatha kupezanso mphamvu. Kubwezeretsanso chonde kumadalira pazinthu zambiri monga:
- Zaka pa nthawi ya chithandizo choyamba
- Chiwerengero cha mayendedwe ndi walitsa ndi othandizira ma alkylating.
Kafukufuku akuti kugwiritsa ntchito njira zonse ziwiri mwachitsanzo ma alkylating agents ndi ma radiation kuphatikiza kungawononge kwambiri chonde cha amayi poyerekeza kugwiritsa ntchito njira imodzi yothandizira. [3]
Komanso, kuchuluka kwa kuchira ndikokwera, pafupifupi 79 peresenti, mwa azimayi omwe ali ndi zaka zosakwana 25 ndipo sanalandirepo mankhwala azowunikira thupi lonse opanda mankhwala opatsirana pogonana, poyerekeza ndi omwe zaka zawo zinali zochulukirapo ndipo alandirako kutentha kwa thupi kwathunthu . [4]
Zochitika Zakale
Nawa owerengeka owerengera omwe angayankhule za azimayi omwe adalowetsedwa m'maselo am'mimba ndi mimba yawo. [5]
Mlanduwu 1: Mayi wina wazaka 22 wosasamala adapatsidwa matenda a gawo lachitatu la Hodgkin. Wadwala chemotherapy maulendo asanu ndi limodzi, ndikutsatiridwa ndi stem cell.
Zotsatira: Anatenga pakati pa mankhwala obwezeretsa mahomoni (HRT) patatha zaka ziwiri atalandira chithandizo chobwezeretsa ndipo adabereka mwana wamwamuna wathanzi kumaliseche.
Mlanduwu 2: Mayi wina wazaka 28 wosasamala anapatsidwa matenda a Hodgkin. Walandira chithandizo cha ma ABVD (adriamycin, bleomycin, velban, ndi DTIC) kasanu ndi kamodzi, ndikutsatiridwa ndi ma cell cell.
Zotsatira: Anamuika pa HRT kwa miyezi itatu ndipo anatenga pakati patatha miyezi isanu ndi umodzi ndikubereka mwana wamkazi mwakachetechete.
Mlanduwu 3: Mayi wazaka 30 wazindikira kuti ali ndi gawo lachitatu lifuwa carcinoma. Analandira mankhwala a chemotherapy maulendo asanu, kenako amatsitsidwa ndi ma cell cell.
Zotsatira: Wodwalayo adakhala ndi pakati patadutsa chaka chimodzi ndi theka kuchokera pamene amuika. Komabe, chifukwa cha zovuta zina zomwe zingachitike chifukwa chothandiziracho, mimba idachotsedwa mchaka choyamba cha trimester chifukwa cha tamoxifen.
Mlanduwu 4: Mayi wazaka 41 anapezeka ndi ductal carcinoma. Anamuchiritsa ndi chemotherapy nthawi zinayi, kenako ndikumuika m'mafupa.
Zotsatira: Pambuyo pa miyezi 16, mayiyu adakhala ndi pakati, komabe, mimbayo idachotsedwa mu trimester yachiwiri chifukwa cha mphamvu ya tamoxifen.
Pomaliza
Amayi omwe amalandira kuwala kwa thupi kwathunthu ayenera kuchitidwa ngati gulu lomwe lili pachiwopsezo chachikulu chifukwa mwayi wokhala ndi pakati ndiwotsika kwambiri mwa azimayiwa. Komanso, mwayi wochotsa mimba mu amayi omwe amathandizidwa ndi amayi ndiwokwera kwambiri.
Kafukufuku amachitika m'derali kuti apange njira zochiritsira zosagwiritsidwa ntchito ndi mankhwala ochepa a alkylating agents kuti kuwonongeka kwa chonde kukhale kochepa kapena kotere komwe kungasinthidwe mosavuta.
Mwanjira imeneyi, azimayi omwe akufuna kukhala ndi pakati atayikidwa maselowo amatha kuchita izi popanda zovuta kapena osagwiritsa ntchito oocyte cryopreservation, njira yomwe mazira amatengedwa kuchokera m'mazira, achisanu ndikusungidwa kuti adzagwiritsenso ntchito pambuyo pake.
