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Zowopsa zomwe zimayambitsa COVID-19 zimaphatikizapo zaka, jenda, matenda oopsa, matenda ashuga komanso kunenepa kwambiri. Posachedwa, umboni wina wamankhwala ndi kafukufuku wasonyeza kuyanjana kotheka pakati pa PCOS ndi COVID-19.
Kafukufukuyu akuti azimayi omwe ali ndi polycystic ovary syndrome (PCOS) kapena polycystic ovarian matenda (PCOD) atha kukhala pachiwopsezo chachikulu chotenga matenda a COVID-19 poyerekeza ndi azimayi omwe alibe PCOS. Nkhaniyi ifotokoza momwe zingathekere komanso chifukwa chake zingatheke. Pemphani kuti mudziwe zambiri.
COVID-19 Ndipo Akazi Akuvutika Ndi PCOS
Malinga ndi kafukufuku wofalitsidwa mu European Journal Of Endocrinology, azimayi omwe ali ndi PCOS ali pachiwopsezo cha 28% chowopsa chotenga kachilombo ka COVID-19 poyerekeza ndi azimayi omwe alibe vutoli. Zotsatirazo zinawerengedwa pambuyo pakusintha zaka, BMI ndi ngozi zowopsa. [1]
Popanda kusintha komwe kwatchulidwaku, kuwunikaku kunawonetsa kuti azimayi a PCOS ali pachiwopsezo chachikulu cha 51V pakati pa azimayi omwe alibe PCOS.
Chifukwa chiyani Odwala a PCOS Ali pachiwopsezo Cha COVID-19?
Kuyambira lero, COVID-19 yakhudza anthu pafupifupi 124 miliyoni padziko lonse lapansi, ndi 70.1 miliyoni omwe adachiritsidwa komanso kufa kwa 2.72 miliyoni. Kafukufuku wambiri wasonyeza kuti milandu yotsimikiziridwa ndi labotale ya COVID-19 imapezeka kwambiri mwa amuna m'maiko angapo poyerekeza ndi akazi.
Ngakhale chifukwa chake chimakhala chochulukirapo, zotsatira za mahomoni a androgen amadziwika kuti ndi chimodzi mwazifukwa zazikulu zakusiyana kwakugonana pamiyeso yamatenda.
Androgen amatchulidwa makamaka ngati mahomoni amphongo omwe amalamulira kukula ndi kukonza mikhalidwe yamwamuna ndi zochitika zawo zoberekera. [ziwiri]
Mahomoniwa amapezeka mwa amuna ndi akazi, koma ntchito yake yayikulu ndikulimbikitsa testosterone ndi androstenedione, awiri mwa mahomoni angapo achimuna.
PCOS ndi vuto la endocrine momwe magawo a androgens (mahomoni amphongo) amatuluka, m'malo mwa estrogen (mahomoni achikazi). Izi zimabweretsa hyperandrogenism komanso kusokonekera kwa kwamchiberekero, kuchititsa kusabereka kwa ena osazindikira bwino komanso kuchiritsidwa.
Popeza mahomoni a androgen amawerengedwa kuti ndiwofunikira pachiwopsezo chotenga kachilombo ka COVID-19, titha kunena kuti azimayi a PCOS amatha kudziwika kwambiri ndi matendawa, poganizira kuti zinthu zina monga kunenepa kwambiri kwa amayi a PCOS zitha kukhalanso chifukwa.
Zinthu Zina
1. Kukaniza kwa insulini
PCOS imalumikizidwa ndi zovuta zamagetsi monga insulin kukana komanso matenda ashuga. Insulin ndi hormone yomwe imathandizira kuthana ndi magulu a shuga m'thupi, komanso kuwongolera kagayidwe kake ka mapuloteni ndi lipids.
Kukana kwa insulin kumachitika thupi likapanda kuyankha insulini, zomwe zimayambitsa kusagwiritsa ntchito shuga m'magazi kufuna mphamvu, zomwe zimapangitsa kuti magazi azikhala ndi shuga wambiri. Kuchuluka kwa shuga kumayamba kusokoneza ma cell amthupi monga B cell, macrophages ndi T cell, zomwe zimapangitsa kuchepa kwa chitetezo cha mthupi.
Kulephera kwa chitetezo cha mthupi chifukwa cha kukana kwa insulin, komwe kudayamba chifukwa cha PCOS kumatha kunena chifukwa chake azimayi omwe ali ndi PCOS akukhudzidwa kwambiri ndi coronavirus. [3]
2. Kunenepa kwambiri
Kafukufuku wasonyeza kuti atangotuluka kumene a coronavirus, pakati pa anthu omwe anali ndi mpweya wabwino, kuchuluka kwa odwala onenepa kwambiri kunali kwakukulu, kutsatiridwa ndi kuchuluka kwakufa pakati pa anthuwa. [4]
Kafukufuku wina wasonyezanso kuti panthawi ya mliri wam'mbuyomu wa matenda a H1N1 kapena chimfine cha nkhumba, kuopsa kwa vutoli kunali kwakukulu mwa anthu onenepa kwambiri. [5]
Pafupifupi azimayi 38-88% omwe ali ndi PCOS amapezeka kuti ndi onenepa kwambiri kapena onenepa kwambiri. Zolumikizana kwambiri pakati pa kunenepa kwambiri, PCOS ndi COVID-19 zitha kumaliza, kuti azimayi a PCOS amatha kutenga COVID-19 chifukwa chonenepa kwambiri kapena onenepa kwambiri.
3. Kulephera kwa Vitamini D
Kulephera kwa Vitamini D kumalumikizidwa ndi PCOS ndi matenda a COVID-19 m'njira zambiri. Vitamini D ndi vitamini wofunikira yemwe angathandize kupewa matenda opatsirana a COVID-19 ndi katundu wake wolimbikitsa chitetezo cha mthupi komanso kuchepetsa zotupa zotupa zomwe zimayambitsa chibayo.
Pafupifupi 67-85% ya azimayi omwe ali ndi PCOS, kuchepa kwa vitamini D kwapezeka. [6]
Kuperewera kwa vitamini D kumatha kuyambitsa kuchepa kwa chitetezo cha mthupi, kuwonjezera ma cytokines otupa komanso chiopsezo chowonjezeka cha comorbidities monga matenda ashuga, insulin kukana komanso kunenepa kwambiri, zovuta zonse za PCOS.
Chifukwa chake, titha kunena kuti kusowa kwa vitamini D kumatha kulumikizidwa ndi PCOS ndikuwonjezera zovuta komanso kuchuluka kwaimfa chifukwa cha COVID-19.
4. Microbiota wabwino
Gut dysbiosis kapena kukanika kwa m'matumbo microbiota kumalumikizidwa ndi thanzi monga PCOS.
PCOS ndi thanzi lamatumbo zimagwirizana. Amayi omwe ali ndi PCOS nthawi zambiri amapezeka ndi m'matumbo dysbiosis. Komabe, ngati milingo ya shuga imayendetsedwa bwino ndipo dongosolo la kugaya limasamalidwa mu PCOS, matumbo amatha kusintha.
Kusintha kwa kapangidwe ka m'matumbo microbiome kumatha kukhudza chitetezo cha mthupi, dongosolo loyambirira la thupi lomwe limatiteteza ku matenda ndipo potero, limatipangitsa kukhala opatsirana ndi matenda monga COVID-19.
Kugwiritsa ntchito maantibiotiki kuti azikhala ndi matumbo ang'onoang'ono am'matumbo kungathandize kulimbitsa chitetezo komanso kupewa chiopsezo cha COVID-19.
Pomaliza
Kukaniza kwa insulin kumatha kukulitsa kutulutsa kwa ma androgens mwa azimayi omwe ali ndi PCOS. Kunenepa kwambiri komanso kunenepa kwambiri kumatha kukulitsa kukana kwa insulin ndipo potero, kumawonjezera kupanga kwa androgen. Izi zitha kuyambitsa vuto la chitetezo cha mthupi chifukwa cha endocrine-immune axis, yomwe itha kukulitsa chiopsezo cha COVID-19 mwa azimayi a PCOS.
